2017 Beckman Scholar Camille Potts from Trinity University published her research in the Journal of Molecular Biology: Functional and Biochemical Characterization of Dib1’s Role in Pre-messenger RNA Splicing.
Highlights retrieved from the journal included:
- Spliceosomal protein Dib1 is centrally located in the putative active site of the spliceosome
- Novel Dib1 mutants stall spliceosome assembly or activation
- Exogeneous Dib1 protein can rescue Dib1 mutants in whole-cell yeast extracts
- Structural analyses suggest that Dib1 mutants functionally affect interactions with other spliceosomal proteins