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Alexander Schuppe, PhD

Alexander Schuppe, PhD
Program:
Beckman Postdoctoral Fellow

Award Year:
2019

Institution:
Massachusetts Institute of Technology

Transfer Institution:

Email:
aschuppe@mit.edu

Research Title:
Enantioselective Hydrocyanation of Alkenes using Dual Metal Catalysis

Chiral nitriles are a ubiquitous and versatile functional group found in numerous pharamaceuticals, materials, and natural products. Although alkene hydrocyanation is conducted on million-ton scale annually to produce polymers, these processes require highly toxic hydrogen cyanide and form exclusively racemic products. This proposal aims to employ a novel approach convert unactivated or minimally activated olefin feedstocks to chiral nitriles by utilizing dual palladium and copper-hydride catalysis with a non-toxic source of cyanide.

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