Enantioselective Hydrocyanation of Alkenes using Dual Metal Catalysis
Chiral nitriles are a ubiquitous and versatile functional group found in numerous pharamaceuticals, materials, and natural products. Although alkene hydrocyanation is conducted on million-ton scale annually to produce polymers, these processes require highly toxic hydrogen cyanide and form exclusively racemic products. This proposal aims to employ a novel approach convert unactivated or minimally activated olefin feedstocks to chiral nitriles by utilizing dual palladium and copper-hydride catalysis with a non-toxic source of cyanide.
Arnold O. Beckman exemplifies the meaning of the word humanitarian. Combined with his unwavering enthusiasm for life, his keen sense of humor and his strong moral and ethical principles, he is a national icon.