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Farren J. Isaacs

Farren J. Isaacs
Program
Beckman Young Investigators

Award Year
2012

Institution
Yale University

Email:
farren.isaacs@yale.edu

Website:
http://isaacslab.yale.edu/

Research Title:
Programming Genomes to Re-engineer Life's Functional Repertoirs

Abstract:
The objective of my research funded by the Arnold and Mabel Beckman Foundation is to develop foundational genome engineering technologies to construct genomically recoded organisms (GROs) possessing a new genetic code that impart novel and orthogonal biological function. Specifically, these GROs could enhance the incorporation of nonstandard amino acids (NSAAs) into proteins to expand the chemical diversity of the proteome and prevent the correct translation of exogenous genetic material, leading to the creation of virus resistant organisms. This research is based on my recent advances in developing genome engineering technologies capable of creating genetic diversity across genes, pathways and whole genomes, and constructing organisms with new genetic codes.

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