•   
  •   
  •   
  •   
  •   

Gabriela Schlau-Cohen

Gabriela Schlau-Cohen
Program
Beckman Young Investigators

Award Year
2016

Institution
Massachusetts Institute of Technology

Email:
gssc@mit.edu

Website:
www.schlaucohenlab.com

Research Title:
Uncovering action at the nanoscale

Abstract:
Overexpression and aberrant activation of the ErbB receptors, a family of mammalian proteins, plays a role in the progression of epithelial and brain tumors. These receptors are a primary target for cancer therapeutics, yet emerging evidence suggests that tumors develop resistance to current therapeutics. We build a mechanistic understanding of receptor response by merging model membrane-protein systems and single-molecule spectroscopy. Our membrane systems provide a near-physiological environment, while single-molecule FRET measurements monitor the conformational dynamics of the receptors. This combination of tools allows us to identify the protein motions to drive the development of new therapeutics.

Go Back