Synthetic Lipid Biology: Membrane Engineering Via Controlled Phospholipid Synthesis In Vivo
Lipids, or fats, are a diverse group of biological molecules that act as energy stores, components of membranes, and initiators of signaling pathways that allows cells to coordinate actions and communicate with one another. These molecules are notoriously challenging to study using traditional genetic and biochemical approaches. Here, I describe a multidisciplinary approach termed "synthetic lipid biology" to create individual lipids on demand within live cells and thus modify membrane content with great precision, for the purpose of studying the effects of individual lipids on cellular behaviors.
Arnold O. Beckman exemplifies the meaning of the word humanitarian. Combined with his unwavering enthusiasm for life, his keen sense of humor and his strong moral and ethical principles, he is a national icon.