Frontier approaches in electron cryo-diffraction to reveal atomic views of complex macromolecular assemblies
For over a century, methods to determine the structures of macromolecules have driven innovations and discoveries in chemistry, biology, and medicine. Recently, a revolution in electron cryo-microscopy has led to the determination of complex biomolecules at near atomic resolution. I propose to extend the frontier of electron scattering technologies to investigate complex, crystalline and semi-ordered molecular assemblies in full atomic detail using electron cryo-diffraction- based methods and instruments.
Arnold O. Beckman exemplifies the meaning of the word humanitarian. Combined with his unwavering enthusiasm for life, his keen sense of humor and his strong moral and ethical principles, he is a national icon.