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Pamela Chang

Pamela Chang
Program
Beckman Young Investigators

Award Year
2017

Institution
Cornell University

Email:
pamela.chang@cornell.edu

Website:
http://www.pamchanglab.com/

Research Title:
Chemical Technologies for Elucidating and Controlling Inflammation

Abstract:
Inflammation is a vital physiological process in infection and tissue repair after injury, but uncontrolled, chronic inflammation occurs in many diseases, including cancer, colitis and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and Type 1 diabetes. Current anti-inflammatory drugs are delivered systemically and cause off-target effects in otherwise healthy tissues, and thus, there is a great demand for next-generation technologies to locally inhibit activation of the immune system, whose cells are the major source of inflammation in vivo, to limit these side effects. In this proposal, we aim to develop precision chemical tools to inhibit local inflammation by modulating the functions of select target populations of immune cells and apply these tools to both study fundamental biological mechanisms of inflammatory pathways and control the immune response in therapeutic settings.

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