Biography
Dr. Johnston joined the Board of Directors in 2016, and has served on the Programs Committee as well as being elected Vice Chair of the Board in 2021.
Research Summary
Small molecule complexity is, and always will be, the foundation of therapeutic development, but synthesis uses this platform as a springboard to more potent and selective tools. In our portfolio of total synthesis, we have reported concise preparations of complex heterocyclic alkaloids serratezomine A and hapalindoles K, A, and G. Our recent work has moved beyond the practice of simply targeting the natural material to include molecularly edited versions (e.g. fluorinated derivatives). These strategic decisions and commitments to provide unique materials create unusual opportunities for collaboration.