Glucose Hypersensitivity in Type-II Diabetic Pancreatic Islets
University of Virginia
School of Medicine
Type-II diabetes is commonly associated with reduced glucose responsiveness in the pancreatic islets. Diabetic islets typically exhibit significantly lower insulin secretion and calcium activity at physiological glucose concentrations (11 mM) when compared to healthy controls. Our studies show that, at low glucoses (8 mM), newly diabetic islets are more responsive than controls, being overly sensitive to glucose. As the mice become more diabetic, this sensitivity is worsened and lower glucose concentrations (5 mM) cause calcium activity to respond as though the islets are in typical glucose concentrations.