20 - Delivering appetite suppression peptides through the vitamin B12 dietary uptake pathway
Obesity has emerged as a significant problem in today€s society. Peptide YY (PYY) has been shown to have clinical relevance in appetite control with studies showing that a truncated form of PYY, PYY3-36, inhibits food intake in rodents, primates, and humans. The anorectic effect PYY3-36 causes is due to agonism of the Y2 receptor in the hypothalamus. The focus of this research is to develop an oral delivery route for exogenous PYY3-36 that elicits in vivo agonism through utilization of the B12 dietary uptake pathway. The hypothesis of the research is that the B12 pathway can be utilized to protect and actively transport select peptides through the gastro-intestinal tract, delivering them to blood. Herein we will discuss the synthesis, characterization, and in vitro pharmacodynamics of two B12-PYY3-36 conjugates with tailored functionality at the Y2 receptor.