Jordan Green, PhD
Nanomedicine: Engineering Cells from the Inside-Out and Outside-In
Johns Hopkins University
Associate Professor of Biomedical Engineering, Ophthalmology, Neurosurgery, and Materials Science & Engineering
The Green lab synthesizes biodegradable polymers to construct nanoparticles that are safe and effective for intracellular delivery of DNA and siRNA and that can be used to engineer target cells from the “inside out.” Additionally, they develop biomimetic nanoparticles that act as artificial antigen presenting cells that can program biological immune cells from the “outside in.” Both of these nanobiotechnologies will be discussed. For intracellular delivery, the effect of differential polymer structure on the delivery of nucleic acids of different structures and sizes will be elucidated. Tuning biomaterial structure enables cell-type specificity of nanoparticles in a range of cell types, including cancer cells vs. healthy cells. The role of particle size and shape in constructing artificial antigen presenting cells and how these biomimetic particles can be used in cancer immunotherapy will be also be presented.