Tony Kim, PhD
Engineering Microsystems for Nanomedicine
Georgia Institute of Technology
George W. Woodruff School of Mechanical Engineering
Nanomedicine is the medical application of nanotechnology for treatment and prevention of major ailments including cancer and cardiovascular diseases. Despite the progress and potential of nanomedicines, many cannot reach clinical trials due to critical challenges including poor reproducibility in high volume production that has led to failure in animal studies and clinical trials. Recent approaches using microfluidic technology have provided emerging platforms with great potential to accelerate the clinical translation of nanomedicine. This talk highlights microfluidic technologies for nanomedicine development and presents two recent approaches, which include (1) the controlled microfluidic formulation of theranostic nanomaterials with high productivity and reproducibility and (2) the development of a simple microchip model for probing nanoparticle translocation over the permeable endothelium in experimental atherosclerosis. These approaches will facilitate the development and optimization of multicomponent theranostic nanomaterials, contributing to a novel therapeutic and diagnostic paradigm for treating major diseases including such as cancer and atherosclerosis. Microfluidic systems applied to nanomedicine is still in its infancy, and will continue to expand towards innovative systems at an industrially relevant scale in the near future.
BIO: Dr. Tony Kim is an Assistant Professor of the George W. Woodruff School of Mechanical Engineering at Georgia Institute of Technology. Dr. Kim’s research focuses on developing biomimetic microsystems that reconstitute organ-level functions on chip and on integrating microfluidic modules with control systems that allow large-scale production of therapeutic and diagnostic bio/nanomaterials. Prior to his current appointment, he was a Postdoctoral Associate in the David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology. In 2011, he received a Ph.D. in Mechanical Engineering from Carnegie Mellon University. His doctorate research focused on development of closed-loop microfluidic control systems for lab-on-a-chip applications to biochemistry and developmental biology. Before joining Carnegie Mellon, he was a researcher in areas of dynamics, controls, and robotics at R&D Divisions of Hyundai-Kia Motors and Samsung Electronics for 6 years. He received Bachelor’s and Master’s degrees in Mechanical Engineering from Seoul National University. He has authored multidisciplinary research articles in major journals including PNAS, Nano Letters, ACS Nano, JACS, PLoS ONE, Lab on a Chip, Microfluidics and Nanofluidics, IEEE Transactions on Control Systems Technology, etc. He has filed over 20 patent applications worldwide, won Dowd-ICES Predoctoral Fellowship and Dean’s Fellowship from Carnegie Mellon, and consulted for biomedical and pharmaceutical companies.