The interfaces between liquids and solids are crucial for a large range of natural and engineered systems, ranging from biomolecular interaction and signal transduction to catalysis and electrochemical energy storage. However, to date these interfacial structures are mostly unknown and are difficult to image due to the delicacy of the liquid environment. The proposed research aims to develop a technique that can, by combining infrared light excitation and ultrasensitive atomic force detection, directly image the chemical structure of liquid-solid interfaces with 3D atomic resolution in real time. We will use this tool to determine the dynamic structure and catalytic activity of enzymes. The results will be critical both for our understanding of biology, and for the design of materials and devices for healthcare and renewable energy.